We recommend the routine use of sperm banks in the cases of men who still wish to have children and who will undergo therapy with 131I activities of 14 GBq or more or in the case of patients with pelvic metastases.Introduction: Pregnancy is a natural phenomenon whose evolution requires routine monitoring in order to promote well-being and comfort to the woman and her family. Becausee we did not perform a spermiogram before therapy, we cannot state that high cumulative 131I activities cause permanent infertility. Oligospermia was common (one third) after high cumulative 131I activities. A generally transient increase in FSH is highly common but is usually reversed within 18 months. We conclude that 131I therapy may cause impairment of testicular function. All patients showed normal testosterone levels. Six months after radioiodine, increased LH levels were observed in only 5 of 52 (9.6%) patients of group 1, which returned to normal after 12 months, and in 5 of 22 (22%) of group 2. In group 2, 12 of 22 (54.5%) patients presented elevated FSH and 8 (66%) of these individuals had oligospermia. FSH values returned to normal after 18 months in all patients. FSH levels were increased 6 months after therapy in all patients of group 1, while a decline was observed after 12 months, with 37 of 52 (71%) subjects presenting normal values. Luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone levels were determined in 52 men with thyroid carcinoma before and 6, 12, and 18 months after radioiodine therapy (3.7–5.5 GBq 131I mean, 4.25 GBq 131I) (group 1) and were also determined before and 18 months after the last radioiodine therapy in 22 patients who received high cumulative activities (13–27.7 GBq mean, 20.3 GBq 131I) (group 2). Our aim was to assess testicular function in patients treated with high-dose radioiodine.
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December 2022
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